The Command Staff of South Carolina Wing consists of four leaders:
Wing Commander - Col Lee Safley
Vice-Commander Operations - Lt Col Chris Paterson
Vice Commander Units - Lt Col Nikki Shaffner
Chief of Staff - Lt Col Bruce Brown
The Wing Commander has overall responsibility for all operations in the wing.
The Vice-Commander is able to represent the Wing Commander during the absence of the Wing Commander. All squadrons report to the Vice Commander.
The Chief of Staff is also able to represent the Wing Commander as necessary. Most directorates and staff positions report to the Chief of Staff, although some report directly to the Wing Commander.